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Target intelligence / Profile preview
Lipase family member K (LIPK)
- Target
- LIPK
- Molecular classification
- Enzyme, Hydrolase (specifically a lipase)
01
Overview
Lipase family member K (LIPK) is an enzyme belonging to the lipase family, predicted to possess lipoprotein lipase activity, and is primarily expressed in keratinocytes where it plays a highly specific role in the terminal steps of differentiation and cornification[1][3][4][6]. It is believed to be essential for lipid metabolism in the most differentiated layers of the epidermis[4][5]. Currently, there is no evidence that LIPK is a therapeutic target, nor are there drugs known to modulate its activity. No direct role in human diseases or safety concerns related to therapeutic modulation have been reported.
- Other names
- LIPL2BA186O14.2bA186O14.2Lipase-like abhydrolase domain-containing protein 2lipase member Klipase Klipase-like, ab-hydrolase domain containing 2
02
Biological functions
Keratinocyte differentiation (last step)Lipid metabolism in differentiated keratinocytesCornification (predicted)
03
Disease associations
Other (No established disease association)
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