Lipase family member N (LIPN)

Lipase family member N (LIPN) is an enzyme belonging to the triglyceride lipase family, involved in hydrolyzing triglycerides into fatty acids and glycerol, thereby playing a key role in lipid metabolism and digestion. LIPN is predominantly expressed in skin, where it contributes to the formation of the skin barrier and normal desquamation processes. Mutations in the LIPN gene have been associated with autosomal recessive congenital ichthyosis, indicating its essential function in skin lipid processing and barrier formation. As a member of the abhydrolase superfamily, it shares structural similarity with other classical lipases, possessing an α/β hydrolase fold and a catalytic triad in its active site. LIPN is considered a potential therapeutic target, particularly in skin disorders related to lipid metabolism, but no drugs are currently known to specifically target this enzyme[1]. *Note:* While information is available for lipase family member N, there are no known drugs or therapeutic interventions directly targeting LIPN as of this review. Most of the mechanistic and structural details in the references pertain to the broader lipase enzyme family[1].

Other names

Lipase member NLIPL4bA186O14.3Lipase-like abhydrolase domain-containing protein 4ARCI8LI4