Drug pipeline
Full profile accessExplore the programs pursuing this target and their development progress.
- Drug candidates
- Developers
- Development stage
Target intelligence / Profile preview
Lipase maturation factor 1 (LMF1)
- Target
- LMF1
- Molecular classification
- Transmembrane protein, Endoplasmic reticulum-associated protein, Protein-folding chaperone
01
Overview
Lipase maturation factor 1 (LMF1) is a membrane-bound protein located in the endoplasmic reticulum, essential for the folding and assembly of a selected group of secreted, dimeric lipases, including lipoprotein lipase, hepatic lipase, and endothelial lipase[1][2][3]. LMF1 interacts with enzymes involved in N-linked glycosylation and endoplasmic reticulum-resident oxidoreductases, supporting the formation and maintenance of correct disulfide bonds during protein maturation. LMF1 also assists the secretion of other disulfide-rich oligomeric proteins such as fibronectin and LDL receptor[2][3]. Mutations in LMF1 can cause combined lipase deficiency and severe hypertriglyceridemia in humans due to impaired lipase activity, confirming its crucial role in human lipid metabolism and redox homeostasis in the ER[1][2][3].
- Other names
- C16orf26TMEM112HMFN1876JFP11FLJ12681FLJ22302TMEM112ATransmembrane protein 112
02
Biological functions
Maturation and folding of dimeric secreted lipases (e.g. lipoprotein lipase, hepatic lipase, endothelial lipase)Contributes to redox homeostasis in the endoplasmic reticulumInteracts with protein disulfide isomerases and N-glycosylation enzymesFacilitates efficient secretion of disulfide-rich oligomeric proteins (fibronectin, LDL receptor)
03
Disease associations
Hypertriglyceridemia due to combined lipase deficiencyPotential contribution to lipid metabolism disorders
04
Safety considerations
Genetic mutations can result in severe metabolic disorders, such as neonatal lethal hyperchylomicronemiaNo known therapeutic safety concerns since LMF1 is not a current drug target
05
Biomarkers
Mutations in LMF1 (e.g. causing truncated DUF1222 domain) as biomarkers for genetic combined lipase deficiency and severe hypertriglyceridemia
Beyond the preview
Go deeper on Lipase maturation factor 1 (LMF1).
Explore the evidence, development activity, and competitive landscape with Gosset’s full data platform.
Clinical trials
Full profile accessFollow the clinical studies evaluating therapies directed at this target.
- Trial design
- Status
- Readouts
Competitive landscape
Full profile accessCompare approaches across drug candidates, modalities, and indications.
- Programs
- Modalities
- Indications
Literature & evidence
Full profile accessInvestigate the research and source evidence behind target biology and development.
- Publications
- Sources
- Analysis
Patents
Full profile accessExplore patent activity around therapies and technologies addressing this target.
- Patents
- Assignees
- Technologies
Research & analysis
Full profile accessConnect target biology, drug development, and emerging evidence in your research.
- Biology
- Development news
- Analysis
Bring the full picture into focus.
See how Gosset can support your research on Lipase maturation factor 1 (LMF1).