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Target intelligence / Profile preview
Lipase maturation factor 2 (LMF2)
- Target
- LMF2
- Molecular classification
- Enzyme maturation factor, Endoplasmic reticulum membrane protein, Protein involved in transport and processing
01
Overview
Lipase maturation factor 2 is a membrane-bound protein essential for the maturation of specific enzymes, notably lipases, within the endoplasmic reticulum. It assists in the proper folding and transport of lipoprotein lipase and may play roles in lipoprotein assembly, lipid metabolism, and certain disease processes. LMF2 is related structurally and functionally to lipase maturation factor 1 and may be implicated in cholesterol-related and neurodegenerative disorders.
- Other names
- TMEM153TMEM112B
02
Mechanism of action
Maturation and transport of active enzymes (e.g., lipases) through the secretory pathway
03
Biological functions
Protein maturation (particularly for lipases)Cellular localization of proteinsLipid metabolism (via processing of lipoprotein lipase)
04
Disease associations
Alzheimer’s disease (altered DNA methylation in the NCAPH2/LMF2 promoter region)Cholestasis-lymphedema syndrome
05
Safety considerations
None specifically reported for targeting LMF2 directly. Potential therapeutic challenges may arise from its role in global protein maturation, risking off-target effects if modulated.
06
Biomarkers
Promoter methylation of LMF2 (especially in Alzheimer’s disease)
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