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Lipase Replacements (PERT)
- Target
- PERT
- Molecular classification
- Enzyme
01
Overview
Lipase replacements are therapeutic preparations containing the enzyme lipase, often combined with amylase and protease, used to treat exocrine pancreatic insufficiency (EPI). These enzymes aid in the digestion of fats, improving nutrient absorption and alleviating symptoms like steatorrhea. Current formulations are primarily derived from porcine sources, with non-animal alternatives under development. Dosing is individualized based on patient weight, age, and dietary fat content.
- Other names
- Pancreatic Enzyme Replacement TherapyPERTCreonZenpepPancreazePertzyeViokaceSollpuraLiprotamase
02
Mechanism of action
Hydrolyzes dietary triglycerides into absorbable free fatty acids and monoglycerides within the small intestine, compensating for insufficient endogenous enzyme secretion.
03
Biological functions
Hydrolysis of dietary triglyceridesFat digestionNutrient absorption
04
Disease associations
Exocrine Pancreatic InsufficiencyChronic PancreatitisCystic FibrosisPancreatic Cancer
05
Safety considerations
Allergic reactions (due to porcine origin)Fibrosing colonopathy (with high doses)Drug interactionsDosing adjustments based on individual needs
06
Interacting drugs
Creon
5 more in the full profile.
07
Biomarkers
SteatorrheaFecal ElastaseCoefficient of Fat Absorption (CFA)
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