Lipid–water and oil–water interfaces

Lipid–water and oil–water interfaces are physical boundaries between immiscible phases that serve as the primary site for lipid metabolism and the action of lipolytic enzymes. These interfaces are characterized by unique thermodynamic properties, such as interfacial tension, which govern the adsorption and activation of proteins like pancreatic lipase (Verger, R., 1997, Trends in Biotechnology). In a therapeutic context, these interfaces are not traditional molecular targets but are critical in the design of lipid-based drug delivery systems (LBDDS), where they influence the solubilization and bioavailability of poorly water-soluble drugs (Pouton, C. W., 2000, Eur J Pharm Sci). Drugs like orlistat exert their effect by preventing the interaction of enzymes with these interfaces, thereby inhibiting the breakdown of dietary fats (PubChem CID 3034010). Furthermore, the stability of these interfaces is essential in pharmaceutical emulsions and the formation of biological membranes, making them a fundamental concept in both physiology and formulation science. Modulating the interfacial environment can also affect signal transduction pathways that rely on the recruitment of proteins to the membrane surface.

Other names

Lipid-aqueous interfaceOil-aqueous interfaceAmphiphilic interfacePhase boundary

Interfacial activation of lipolytic enzymes and modulation of surface tension to facilitate or inhibit lipid processing and drug delivery.