Lipid bilayer of cell membranes (None)

The lipid bilayer of cell membranes consists of two sheets of amphipathic lipid molecules, primarily phospholipids, with hydrophilic heads facing the aqueous environment and hydrophobic tails sequestered inward[1][3][5][7][9]. This structure forms a dynamic, self-sealing barrier that is largely impermeable to water-soluble molecules and ions, necessitating specialized protein channels and transporters for regulated passage[1][3][7][9]. Membrane proteins are embedded in or associated with the bilayer, enabling signaling, transport, and enzymatic activities[2][5][7][8]. The bilayer is fluid due to lateral movement of lipids and proteins, which is essential for membrane function; fluidity is modulated by fatty acid properties and the presence of cholesterol[5][7]. The lipid bilayer is crucial for maintaining cellular homeostasis and compartmentalization but is not typically a direct drug target; it is, however, affected by toxins, certain drugs, and disease processes[8][9].

Other names

Lipid bilayerphospholipid bilayercell membrane bilayerbiological membrane bilayer

Disruption of membrane integrity or permeability (e.g., pore formation by toxins); Alteration of membrane fluidity or lipid composition, modifying function of embedded proteins; Use of artificial lipid bilayers for drug delivery (liposomes)