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Lipid II
- Molecular classification
- Small molecule, Peptidoglycan precursor
01
Overview
Lipid II is a crucial precursor in the biosynthesis of bacterial cell walls, serving as the immediate building block for peptidoglycan. It is an amphipathic molecule featuring a long bactoprenol hydrocarbon chain that acts as a lipid anchor, embedding Lipid II into the bacterial cytoplasmic membrane. It is targeted by several classes of antibiotics, including glycopeptides (e.g., vancomycin) and lantibiotics (e.g., nisin).
- Other names
- Undecaprenyldiphospho-N-acetyl-(N-acetylglucosaminyl)muramoyl peptideGlcNAc-(1→4)-MurNAc(oyl-L-Ala-gamma-D-Glu-L-Lys-D-Ala-D-Ala)-diphosphoundecaprenolCHEBI:27692C05893
02
Mechanism of action
Blocking incorporation into peptidoglycan, disrupting cell wall synthesis, forming pores in membranes
03
Biological functions
Cell wall biosynthesisPeptidoglycan synthesisCell division
04
Disease associations
Infection
05
Safety considerations
Antibiotic resistance
06
Interacting drugs
Vancomycin
1 more in the full profile.
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