Target intelligence / Profile preview

Lipid II D-Ala-D-Ala Precursor

Molecular classification: Metabolic intermediate, Cell wall precursor, Lipoglycopeptide

Overview

Lipid II D-Ala-D-Ala precursor is a central molecule in bacterial cell wall biosynthesis. It serves as the immediate substrate for peptidoglycan polymerization, which is essential for maintaining bacterial cell shape and integrity. The molecule consists of a disaccharide-pentapeptide (N-acetylglucosamine–N-acetylmuramic acid linked to a pentapeptide ending in D-alanyl-D-alanine) attached to a bactoprenol lipid anchor that embeds it in the cytoplasmic membrane.

Mechanism of action

Inhibition of peptidoglycan synthesis by binding to the D-Ala-D-Ala terminus, preventing incorporation into the growing cell wall.

Biological functions

Peptidoglycan biosynthesisCell wall synthesisBacterial cell integrity

Disease associations

Infection

Safety considerations

Development of antibiotic resistance (e.g., D-Ala to D-Lac substitution)

Interacting drugs

Vancomycin

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