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Lipid Metabolism Pathway
- Molecular classification
- Metabolic Pathway, Enzymatic Cascade
01
Overview
The lipid metabolism pathway encompasses all major steps from dietary fat digestion through cellular uptake/storage/synthesis/breakdown—integrating with carbohydrate metabolism at multiple points—and is tightly regulated by hormonal signals and transcriptional networks involving SREBPs and PPARs. Dysregulation is linked with metabolic syndrome, obesity, diabetes mellitus type II, and cardiovascular disease.
- Other names
- Fat MetabolismLipogenesisLipolysisFatty Acid MetabolismTriglyceride MetabolismCholesterol Metabolism
02
Mechanism of action
Varied; depends on the specific enzyme or regulator targeted. Examples include: - Inhibition of cholesterol synthesis - Activation of fatty acid oxidation - Inhibition of fat absorption
03
Biological functions
Energy ProductionEnergy StorageCell Membrane StructureHormone SynthesisSignal Transduction
04
Disease associations
ObesityMetabolic SyndromeType 2 Diabetes MellitusCardiovascular DiseaseNon-alcoholic Fatty Liver Disease (NAFLD)Hyperlipidemia
05
Safety considerations
Drug-induced liver injuryMuscle pain (statin-associated myopathy)Gastrointestinal side effectsIncreased risk of gallstones (fibrates)Weight gain (thiazolidinediones)
06
Interacting drugs
Statins (HMG-CoA Reductase Inhibitors)
4 more in the full profile.
07
Biomarkers
TriglyceridesTotal CholesterolLDL CholesterolHDL CholesterolFatty Acid ProfileApolipoproteins (e.g., ApoB, ApoA-I)Liver Enzymes (e.g., ALT, AST)Insulin Resistance (HOMA-IR)
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