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Lipid Peroxidation
- Molecular classification
- Chemical process, Oxidative damage
01
Overview
Lipid peroxidation is a chemical process in which oxidants, particularly free radicals, attack lipids containing carbon-carbon double bonds—most notably polyunsaturated fatty acids (PUFAs)—resulting in oxidative degradation of these lipids. This process is a major form of oxidative damage in biological systems and plays a significant role in cell injury, aging, and various diseases.
02
Mechanism of action
Neutralizing reactive intermediates, terminating propagation phase
03
Biological functions
Degradation/alteration of membrane lipidsSignalingInvolvement in cell deathDisruption of membrane structure and function
04
Disease associations
Neurodegenerative diseasesCardiovascular disordersCancerInflammatory responsesCell injury/deathAging
05
Safety considerations
CytotoxicityMutagenesisFurther breakdown into secondary toxic compounds
06
Interacting drugs
Vitamin E
1 more in the full profile.
07
Biomarkers
Malondialdehyde (MDA)4-Hydroxynonenal (4-HNE)Lipid hydroperoxides (LOOH)
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