Lipid Peroxidation Pathway (LPP)

The lipid peroxidation pathway is a series of chemical reactions in which oxidants attack lipids, especially polyunsaturated fatty acids (PUFAs), leading to their oxidative degradation. It is a major form of oxidative damage in biological systems and is implicated in various diseases, including atherosclerosis, neurodegeneration, and cancer. The pathway involves initiation, propagation, and termination phases, with key products like MDA, 4-HNE, and isoprostanes serving as biomarkers. Regulation involves enzymatic and non-enzymatic antioxidant defenses. While not a single druggable target, modulating the pathway via antioxidants or specific enzyme inhibitors is a therapeutic strategy.

Other names

Lipid peroxidationLPOAutoxidation of lipids

Modulation of oxidative stress, scavenging of free radicals, inhibition of lipid peroxidation enzymes (e.g., LOXs), iron chelation.