Lipid peroxidation pathway enzyme

**Lipid peroxidation pathway enzymes** is not a single molecular target but rather refers to a group of enzymes that catalyze or regulate the oxidative degradation of lipids. This process involves the attack of reactive oxygen species (ROS) on polyunsaturated fatty acids within cell membranes, leading to the formation of lipid radicals and ultimately lipid hydroperoxides and various aldehydic byproducts such as malondialdehyde and 4-hydroxynonenal. The enzymatic pathways include cyclooxygenases, lipoxygenases, and cytochrome P450s among others; these are responsible for initiating or propagating lipid oxidation reactions in biological systems[5]. Lipid peroxidation plays a central role in several forms of regulated cell death—most notably ferroptosis—and is implicated in numerous pathological conditions including cancer, neurodegeneration, and inflammatory diseases due to its ability to damage DNA, proteins, membranes and disrupt cellular homeostasis[1][2][3]. Biomarkers such as MDA and 4-HNE are commonly used to assess the extent of lipid peroxidation in clinical settings. Because "Lipid peroxidation pathway enzymes" refers collectively to multiple distinct proteins rather than a single defined molecular entity or drug target—and lacks specificity regarding which enzyme(s) are meant—this entry should be considered incorrect for structured drug-target databases. For accurate data curation or therapeutic targeting purposes it is necessary to specify individual enzyme names such as "Cyclooxygenase 2", "Lipoxygenase", etc.[5]

Other names

Lipid peroxidation enzymesEnzymes involved in lipid peroxidationOxidative lipid metabolism enzymes