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Lipid Peroxidation Product
- Molecular classification
- Small molecule, Metabolite, Aldehyde, Hydroperoxide
01
Overview
Lipid peroxidation products are a diverse group of molecules generated during the oxidative degradation of lipids, particularly polyunsaturated fatty acids (PUFAs), in biological membranes. This process is initiated by reactive oxygen species (ROS) or free radicals and results in primary products like lipid hydroperoxides (LOOH) and secondary products like malondialdehyde (MDA) and 4-hydroxynonenal (4-HNE). These products can modify proteins and DNA, contributing to cellular dysfunction and various diseases, including cancer, atherosclerosis, and neurodegenerative disorders.
- Other names
- LOOH (Lipid hydroperoxides)MDA (Malondialdehyde)4-HNE (4-hydroxynonenal)
02
Mechanism of action
N/A
03
Biological functions
Oxidative stress mediatorProtein modificationDNA modificationCell signalingInitiation of inflammatory responses
04
Disease associations
CancerAtherosclerosisNeurodegenerative diseaseAlzheimer's diseaseAgingOxidative stress-related diseases
05
Safety considerations
CytotoxicityMutagenicityFormation of protein and DNA adducts
06
Interacting drugs
Antioxidants (e.g., Vitamin E)
1 more in the full profile.
07
Biomarkers
Malondialdehyde (MDA)4-hydroxynonenal (4-HNE)Isoprostanes
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