Lipid phosphate phosphohydrolase 3 (PLPP3)

Lipid phosphate phosphohydrolase 3 (PLPP3) is an integral membrane enzyme that hydrolyzes extracellular and intracellular lipid phosphate substrates, such as lysophosphatidic acid and sphingosine 1-phosphate, thereby terminating their signaling. This activity is critical for regulating vascular and embryonic development, maintaining vascular integrity, modulating cell survival, proliferation, and migration, and controlling inflammation. PLPP3 is ubiquitously expressed and is encoded by the *PPAP2B* gene, a locus associated with coronary artery disease risk in humans. Genetic deletion leads to defective embryogenesis and vascular abnormalities, while dysregulation is implicated in atherosclerosis, cancer, and other diseases. No approved drugs are known to directly target PLPP3, but it serves as a key node in lipid signaling pathways of significant pathophysiological relevance[1][2][3][7].

Other names

Phospholipid phosphatase 3LPP3PPAP2BPAP-2bPAP2bVCIPlipid phosphate phosphohydrolase 3phosphatidate phosphohydrolase type 2bphosphatidic acid phosphatase 2bvascular endothelial growth factor and type I collagen-inducible proteinDri42PAP2 beta

Termination of LPA and S1P signaling by dephosphorylation, thus modulating pathways involved in cell migration, angiogenesis, inflammation, and permeability[1][3][7] Experimental: pharmacological inhibitors/antagonists reduce effects mediated by LPA or S1P, not necessarily by direct inhibition of PLPP3