Lipid synthesis enzymes

Lipid synthesis enzymes are a diverse group of metabolic enzymes responsible for the anabolic synthesis of fatty acids, triglycerides, phospholipids, cholesterol, and other lipids[1][2][4]. Major enzymes include acetyl-CoA carboxylase (ACC), fatty acid synthase (FASN), glycerol-3-phosphate acyltransferase (GPAT), acylglycerophosphate acyltransferase (AGPAT), diacylglycerol acyltransferase (DGAT), phosphatidic acid phosphatase (lipins), and 3-hydroxy-3-methylglutaryl-CoA reductase (HMG-CoA reductase)[1][2]. These enzymes play essential roles in energy storage, membrane formation, and cellular signaling[1][3]. Dysregulation of lipid synthesis enzymes has been linked to cancer, metabolic, and cardiovascular diseases[1]. Although drugs such as statins and ACC inhibitors target specific lipid synthesis enzymes for therapeutic benefit, the term "lipid synthesis enzymes" itself is not a singular molecular target and thus is too non-specific for canonical targeting[1][2]. Note: "Lipid synthesis enzymes" is a collective term; for targeting and precise data, refer to individual enzymes (e.g., "Acetyl-CoA carboxylase", "Fatty acid synthase", "HMG-CoA reductase")[1][2][3][4].

Other names

lipogenic enzymesenzymes of lipid biosynthesislipogenesis enzymes

Enzyme inhibition (e.g., blocking catalytic activity to reduce lipid biosynthesis); Allosteric modulation