Drug pipeline
Full profile accessExplore the programs pursuing this target and their development progress.
- Drug candidates
- Developers
- Development stage
Target intelligence / Profile preview
Lipin 1 (LPIN1)
- Target
- LPIN1
- Molecular classification
- Enzyme, Phosphatidate Phosphatase, Transcriptional Coactivator
01
Overview
Lipin 1 is a multifunctional protein that functions as a phosphatidate phosphatase, converting phosphatidic acid to diacylglycerol, and as a transcriptional coactivator regulating genes involved in lipid metabolism and energy balance. It plays a critical role in glycerolipid synthesis, adipocyte differentiation, and the regulation of fatty acid oxidation. Mutations in LPIN1 are associated with recurrent rhabdomyolysis and a predisposition to statin-induced myopathy. It is also implicated in lipodystrophy syndromes.
02
Mechanism of action
Phosphatidate phosphatase activity (conversion of phosphatidic acid to diacylglycerol); Transcriptional coactivation of nuclear receptors (e.g., PPARα, PGC-1α)
03
Biological functions
Glycerolipid synthesisTriglyceride storageAdipocyte differentiationRegulation of fatty acid oxidationPI3K-AKT-mTOR pathway modulationLipid metabolismMetabolic homeostasis
04
Disease associations
RhabdomyolysisMyopathyLipodystrophyFatty liver diseaseInsulin resistance
05
Safety considerations
RhabdomyolysisMyopathy
06
Interacting drugs
Statins (implicated in myopathy predisposition)
Beyond the preview
Go deeper on Lipin 1 (LPIN1).
Explore the evidence, development activity, and competitive landscape with Gosset’s full data platform.
Clinical trials
Full profile accessFollow the clinical studies evaluating therapies directed at this target.
- Trial design
- Status
- Readouts
Competitive landscape
Full profile accessCompare approaches across drug candidates, modalities, and indications.
- Programs
- Modalities
- Indications
Literature & evidence
Full profile accessInvestigate the research and source evidence behind target biology and development.
- Publications
- Sources
- Analysis
Patents
Full profile accessExplore patent activity around therapies and technologies addressing this target.
- Patents
- Assignees
- Technologies
Research & analysis
Full profile accessConnect target biology, drug development, and emerging evidence in your research.
- Biology
- Development news
- Analysis
Bring the full picture into focus.
See how Gosset can support your research on Lipin 1 (LPIN1).