Lipocalin-1-interacting membrane receptor (LIMR)

The Lipocalin-1-interacting membrane receptor (LIMR) is a membrane protein that mediates the endocytic uptake of Lipocalin-1, a broadly ligand-specific extracellular protein involved in the scavenging and removal of lipophilic and potentially harmful molecules[2]. LIMR structurally comprises nine putative transmembrane domains, a short extracellular region for ligand binding, and a large intracellular loop, distinguishing it from other endocytic receptors such as megalin[2]. This receptor is essential for internalizing Lipocalin-1-ligand complexes, facilitating detoxification, immunomodulation, antimicrobial defense (binding bacterial/fungal siderophores), and regulating tissue homeostasis[1][2][7]. LIMR is encoded on chromosome 12p11 and is highly conserved across species, highlighting its fundamental biological role[2]. Elevated Lipocalin-1 expression serves as a biomarker for cellular stress, inflammation, and select pathological conditions[1].

Other names

LIMRLipocalin-1 receptorLipocalin-interacting membrane receptor

Endocytosis of Lipocalin-1-ligand complexes, leading to intracellular processing and detoxification\nScavenging and internalization of potentially harmful hydrophobic or toxic molecules when complexed with Lipocalin-1