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Lipocalin 8 (LCN8)
- Target
- LCN8
- Molecular classification
- Lipocalin family, Calycin structural superfamily, Small hydrophobic ligand-binding protein
01
Overview
Lipocalin 8 (LCN8) is an epididymal-specific member of the lipocalin family, characterized by an 8-stranded antiparallel beta-barrel forming a cup-shaped ligand-binding pocket, primarily expressed in the proximal epididymis[1][2]. LCN8 plays a key role in establishing and maintaining the differentiated state of epididymal epithelial cells, supports sperm maturation, and is likely involved in the transport of small hydrophobic metabolites or molecules essential for reproductive biology[1]. Although LCN8 is a useful marker for initial segment-specific expression and fertility research, it does not currently have demonstrated roles in disease or drug interactions and is not an established therapeutic target[3].
- Other names
- Lipocalin 8LCN8LCN5EP17Epididymal-specific lipocalin-8Epididymis secretory sperm binding proteinLipocalin 5
02
Biological functions
Sperm maturationTransport of small hydrophobic moleculesDifferentiation and maintenance of epididymal epithelium
03
Disease associations
Deficiency causes sperm maturation defects in mice, impacting male fertility, but no direct disease association in humans is established
04
Biomarkers
Marker for epididymal initial segmentMarker for specialized male reproductive functions
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