Lipogenic gene expression in adipose tissue

"Lipogenic gene expression in adipose tissue" refers to the collective activity of genes responsible for synthesizing fatty acids and triglycerides within fat cells. This includes key enzymes like fatty acid synthase (FASN), acetyl-CoA carboxylase (ACC), stearoyl-CoA desaturase 1 (SCD1), and regulatory proteins such as peroxisome proliferator–activated receptor gamma (PPARγ) and sterol regulatory element-binding protein 1c (SREBP‑1c). These genes are regulated by nutritional status, hormones like insulin and leptin, and various metabolic signals. In humans, especially under conditions like obesity or overnutrition, dysregulation of these pathways contributes to excessive fat accumulation in adipose tissue but also impacts systemic metabolism. While individual components are considered therapeutic targets for obesity-related diseases or diabetes management, "lipogenic gene expression in adipose tissue" is not itself a single molecular target but rather describes a complex biological process involving multiple molecules.

Modulation of transcription factors such as SREBP-1c and PPARγ that regulate lipogenic genes; Hormonal regulation by insulin and leptin affecting the expression of lipogenic enzymes