Lipolysis-related protein (LRP)

The term "Lipolysis-related protein" is generally used as a descriptive category for a group of enzymes and regulatory proteins that mediate the breakdown of triglycerides into glycerol and free fatty acids, a process known as lipolysis. Key members of this class include Adipose Triglyceride Lipase (ATGL), Hormone-Sensitive Lipase (HSL), and the Lipolysis-Stimulated Lipoprotein Receptor (LSR). These proteins are primarily located in adipose tissue and the liver, where they play critical roles in energy homeostasis and the systemic clearance of lipoproteins. Dysregulation of lipolysis-related proteins is central to the pathogenesis of metabolic disorders such as obesity, type 2 diabetes, and dyslipidemia, as well as wasting syndromes like cancer cachexia. Therapeutic strategies targeting these proteins involve either inhibiting excessive lipolysis to prevent fatty acid-induced insulin resistance or stimulating lipolytic pathways to reduce adipose mass. While specific inhibitors like Atglistatin are used in research, clinical applications often involve broader metabolic modulators or drugs targeting specific members like lipoprotein lipase (LPL) via gene therapy or antisense oligonucleotides.

Other names

Lipolytic proteinsLipolysis-associated proteinsLipolysis-stimulated receptorLipolysis-stimulated lipoprotein receptor

Inhibition or activation of triglyceride hydrolysis by targeting key lipases such as adipose triglyceride lipase (ATGL) and hormone-sensitive lipase (HSL), or modulating the clearance of triglyceride-rich lipoproteins via receptors like the lipolysis-stimulated lipoprotein receptor (LSR).