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Lipooxygenase Pathway (None)

Target: None
Molecular classification: Enzyme-mediated metabolic pathway, Signaling pathway

Overview

The lipooxygenase (LOX) pathway refers to a series of biochemical reactions catalyzed by lipoxygenase enzymes. These enzymes metabolize polyunsaturated fatty acids such as arachidonic acid, leading to the production of bioactive lipid mediators called eicosanoids. The pathway plays critical roles in inflammation, vascular biology, and diseases like asthma and atherosclerosis.

Mechanism of action

Inhibition of lipoxygenase enzymes, antagonism of leukotriene receptors

Biological functions

Inflammatory response modulationVascular tone regulationEicosanoid synthesis

Disease associations

AsthmaAllergyCardiovascular diseaseAtherosclerosisInflammation

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