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Lipopolysaccharide O-polysaccharide of Pseudomonas aeruginosa serotype O11 (LPS O-polysaccharide O11)
- Target
- LPS O-polysaccharide O11
- Molecular classification
- Polysaccharide, Lipopolysaccharide (LPS), O-antigen
01
Overview
The lipopolysaccharide (LPS) O-polysaccharide, specifically from Pseudomonas aeruginosa serotype O11, is a crucial component of the bacterial outer membrane and a key virulence factor. Its repeating unit consists of [-3)-α-L-FucNAc-(1→3)-β-D-FucNAc-(1→2)-β-D-Glc-(1-]. The biosynthetic gene cluster includes genes like wzzPaO111, wzxPaO11, wbjA-wbjF, wzyPaO11, and wbpLO11/wbpMO11. This O-antigen is important for immune evasion, biofilm formation, and virulence. Serotype O11 strains are often associated with multidrug resistance, making this LPS a significant target for therapeutic intervention. However, structural variability poses challenges for vaccine development.
- Other names
- O-antigen of Pseudomonas aeruginosa serotype O11P. aeruginosa O11 O-polysaccharideB-band polysaccharide O11OSA O11
02
Biological functions
Immune evasionBiofilm formationVirulenceAdhesionStructural component of bacterial outer membrane
03
Disease associations
InfectionPseudomonas aeruginosa infectionHospital-acquired infectionsMultidrug resistance
04
Safety considerations
Structural heterogeneity across strains complicates vaccine developmentAssociation with multidrug-resistant strains
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