Lipoprotein(a)-like 2 (LPAL2)

Lipoprotein(a)-like 2 (LPAL2) is a human pseudogene, formerly hypothesized to code for a protein similar in structure to lipoprotein(a), which is implicated in lipid metabolism and cardiovascular disease via its major protein component, apolipoprotein(a)[2][5]. LPAL2, however, does not produce a functional protein in humans and is classified as a pseudogene, meaning it is a genomic DNA sequence similar to a functional gene but typically non-coding and without established biological or clinical relevance[5]. While early references mention possible roles in lipid metabolism or inflammation, there is no direct evidence supporting any function or therapeutic targeting of LPAL2 in humans[5]. LPAL2 should not be confused with Lipoprotein(a) or its main functional component, apolipoprotein(a), both of which are clinically relevant for cardiovascular disease[3][4]. LPAL2 is not a component of functional lipoprotein particles and does not have known roles in human physiology[5]. No drugs, biomarkers, or disease associations are known for LPAL2[5].

Other names

APOARGCApo(a)-like protein 2Lp(a)-like protein 2Apo(a)rg-CApolipoprotein a-related gene C proteinAPOALAPOA2