Target intelligence / Profile preview

Lipoprotein A (Lp(a))

Target: Lp(a)
Molecular classification: Lipoprotein, Apolipoprotein

Overview

Lipoprotein(a), or Lp(a), is a lipoprotein particle structurally similar to LDL, but with an additional protein, apolipoprotein(a) [apo(a)], covalently attached. Elevated Lp(a) levels are an independent genetic risk factor for cardiovascular diseases due to its roles in atherogenesis, thrombogenesis, and inflammation. It acts as a carrier for cholesterol and oxidized phospholipids. The precise physiological function of Lp(a) remains unclear.

Other names: Lipoprotein (a)Cholesterol Lp[a]Lp[a]

Biological functions

Cholesterol transportOxidized phospholipid transportVascular repair (potential)Wound healing (potential)

Disease associations

AtherosclerosisCoronary artery diseaseHeart attackStrokePeripheral arterial diseaseThrombosisInflammation

Safety considerations

Elevated Lp(a) levels are a genetic risk factor, difficult to modify with lifestyle changesPotential for increased thrombotic risk

Biomarkers

Plasma Lp(a) concentration

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