Target intelligence / Profile preview

Lipoprotein A mRNA (Lp(a) mRNA)

Target: Lp(a) mRNA
Molecular classification: mRNA, Gene Product

Overview

Lipoprotein(a) [Lp(a)] mRNA is the messenger RNA transcribed from the *LPA* gene, encoding apolipoprotein(a) [apo(a)]. The *LPA* gene contains a variable number of kringle IV type 2 (KIV-2) repeats, leading to significant size polymorphism. Lp(a) mRNA is primarily synthesized in the liver. Therapies targeting Lp(a) mRNA, such as antisense oligonucleotides (ASOs) and siRNAs, aim to reduce hepatic production of apo(a), thereby lowering circulating Lp(a) concentrations, an independent risk factor for cardiovascular disease.

Other names: Apolipoprotein(a) mRNALPA mRNA

Mechanism of action

Antisense oligonucleotide (ASO) mediated degradation or translational inhibition; siRNA mediated cleavage

Biological functions

Template for Apolipoprotein(a) synthesisRegulation of Lipoprotein(a) levels

Disease associations

Cardiovascular diseaseAtherosclerosisThrombosis

Safety considerations

Off-target effects of RNA-based therapeuticsImmune response to RNA therapeuticsLong-term effects of Lp(a) reduction

Interacting drugs

Pelacarsen

3 more in the full profile.

Biomarkers

Lipoprotein(a) plasma levelsApolipoprotein(a) isoform size

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