Drug pipeline
Full profile accessExplore the programs pursuing this target and their development progress.
- Drug candidates
- Developers
- Development stage
Target intelligence / Profile preview
Lipoprotein-associated Phospholipase A2 (Lp-PLA2)
- Target
- Lp-PLA2
- Molecular classification
- Enzyme, Phospholipase A2 superfamily, Hydrolase
01
Overview
Lipoprotein-associated phospholipase A2 (Lp-PLA2) is a secreted enzyme that hydrolyzes oxidized phospholipids and platelet activating factor (PAF), generating pro-inflammatory mediators. Primarily produced by inflammatory cells and transported by LDL and HDL, Lp-PLA2 is associated with increased risk for cardiovascular diseases and serves as a potential therapeutic target for vascular inflammation and atherosclerosis. Unlike general inflammatory markers, Lp-PLA2 is a vascular-specific biomarker.
- Other names
- Platelet-activating factor acetylhydrolase (PAF-AH)LDL-PLA2PAFAHPhospholipase A2 group VII
02
Mechanism of action
Inhibition of Lp-PLA2 enzymatic activity to reduce vascular inflammation and prevent the formation of proatherogenic lipid mediators.
03
Biological functions
Hydrolysis of phospholipidsDegradation of PAFProduction of lysophosphatidylcholineProduction of oxidized nonesterified fatty acidsVascular inflammationAtherosclerosis
04
Disease associations
Cardiovascular diseaseCoronary artery diseaseStrokeAtherosclerosis
05
Biomarkers
Elevated Lp-PLA2 levels in plasmaVascular inflammation
Beyond the preview
Go deeper on Lipoprotein-associated Phospholipase A2 (Lp-PLA2).
Explore the evidence, development activity, and competitive landscape with Gosset’s full data platform.
Clinical trials
Full profile accessFollow the clinical studies evaluating therapies directed at this target.
- Trial design
- Status
- Readouts
Competitive landscape
Full profile accessCompare approaches across drug candidates, modalities, and indications.
- Programs
- Modalities
- Indications
Literature & evidence
Full profile accessInvestigate the research and source evidence behind target biology and development.
- Publications
- Sources
- Analysis
Patents
Full profile accessExplore patent activity around therapies and technologies addressing this target.
- Patents
- Assignees
- Technologies
Research & analysis
Full profile accessConnect target biology, drug development, and emerging evidence in your research.
- Biology
- Development news
- Analysis
Bring the full picture into focus.
See how Gosset can support your research on Lipoprotein-associated Phospholipase A2 (Lp-PLA2).