Target intelligence / Profile preview

Lipoprotein Lipase

Molecular classification: Enzyme, Lipase

Overview

Lipoprotein lipase (LPL) is a water-soluble enzyme that hydrolyzes triglycerides present in circulating chylomicrons and very low-density lipoproteins (VLDL), releasing free fatty acids and glycerol. It plays a central role in lipid metabolism and is primarily found in adipose tissue, skeletal muscle, and heart tissue.

Mechanism of action

Hydrolyzes triglycerides in chylomicrons and VLDL, releasing free fatty acids and glycerol.

Biological functions

Triglyceride hydrolysisFatty acid releaseLipid metabolismEnergy homeostasis

Disease associations

HypertriglyceridemiaAtherosclerosisObesityDiabetesAlzheimer's DiseaseDyslipidemia

Safety considerations

Pancreatitis (in severe deficiency)Hypertriglyceridemia

Biomarkers

LPL activityTriglyceride levelsApoC-II levels

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