Drug pipeline
Full profile accessExplore the programs pursuing this target and their development progress.
- Drug candidates
- Developers
- Development stage
Target intelligence / Profile preview
Lipoxin pathway (LX pathway)
- Target
- LX pathway
- Molecular classification
- Lipid mediator pathway, Bioactive lipid mediator, Receptor-mediated signaling pathway
01
Overview
The Lipoxin pathway is a complex biochemical pathway involved in the resolution of inflammation. It is mediated by bioactive lipids, particularly lipoxin A4 and B4, which are derived from arachidonic acid. These lipoxins act on specific receptors like FPR2/ALX to inhibit leukocyte recruitment, promote phagocytosis of apoptotic cells, and reduce inflammation, thereby contributing to tissue homeostasis and repair. They are considered potential therapeutic targets for treating chronic inflammatory disorders.
- Other names
- Lipoxin metabolismLipoxin biosynthesisLipoxin signaling
02
Mechanism of action
Inhibition of pro-inflammatory signaling pathways (e.g., NF-κB, PI3K/Akt); Promotion of anti-inflammatory signaling pathways (e.g., NRF2); Stimulation of macrophage phagocytosis
03
Biological functions
Resolution of inflammationImmune response modulationCell proliferation inhibitionPhagocytosis of apoptotic cellsSignal transduction
04
Disease associations
InflammationCardiovascular diseaseRenal fibrosisDiabetic kidney diseaseCancer
05
Safety considerations
The rapid metabolism of lipoxins may limit their therapeutic efficacy.
06
Interacting drugs
Aspirin (enhances lipoxin production)
1 more in the full profile.
07
Biomarkers
Lipoxin A4 and B4 levels (for monitoring inflammation resolution)
Beyond the preview
Go deeper on Lipoxin pathway (LX pathway).
Explore the evidence, development activity, and competitive landscape with Gosset’s full data platform.
Clinical trials
Full profile accessFollow the clinical studies evaluating therapies directed at this target.
- Trial design
- Status
- Readouts
Competitive landscape
Full profile accessCompare approaches across drug candidates, modalities, and indications.
- Programs
- Modalities
- Indications
Literature & evidence
Full profile accessInvestigate the research and source evidence behind target biology and development.
- Publications
- Sources
- Analysis
Patents
Full profile accessExplore patent activity around therapies and technologies addressing this target.
- Patents
- Assignees
- Technologies
Research & analysis
Full profile accessConnect target biology, drug development, and emerging evidence in your research.
- Biology
- Development news
- Analysis
Bring the full picture into focus.
See how Gosset can support your research on Lipoxin pathway (LX pathway).