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Lipoxygenase (None)
- Target
- None
- Molecular classification
- Enzyme, Non-heme iron dioxygenase
01
Overview
Lipoxygenases (LOXs) are a family of non-heme iron-containing enzymes that catalyze the dioxygenation of polyunsaturated fatty acids, producing hydroperoxides. These enzymes are found in plants, animals, and some prokaryotes, with diverse physiological and pathophysiological roles. Dysregulated LOX activity is implicated in inflammatory diseases, asthma, certain cancers, neurodegenerative disorders, and genetic skin disorders like ichthyosis. Pharmacological targeting, especially inhibition, of specific LOXs is under investigation for therapeutic purposes.
- Other names
- LOXArachidonate lipoxygenaseLinoleate dioxygenase
02
Mechanism of action
Inhibition of lipoxygenase activity to reduce the production of lipid mediators.
03
Biological functions
Lipid mediator biosynthesisInflammation regulationSkin barrier functionDioxygenation of polyunsaturated fatty acids
04
Disease associations
Inflammatory diseasesAsthmaCancerNeurodegenerative disordersIchthyosis
05
Safety considerations
Potential for off-target effects due to multiple isoformsDysregulation of lipid signaling pathways
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