Target intelligence / Profile preview

Lipoxygenase-Cyclooxygenase (LOX-COX)

Target: LOX-COX
Molecular classification: Enzyme, Oxidoreductase

Overview

Lipoxygenases (LOX) and cyclooxygenases (COX) are two distinct families of enzymes that catalyze the oxygenation of polyunsaturated fatty acids, such as arachidonic acid, leading to the production of various bioactive lipid mediators known as eicosanoids. These enzymes play crucial roles in inflammation, cancer progression, and other physiological and pathological processes. They are major drug targets for inflammatory diseases and cancer.

Other names: Arachidonate LipoxygenasesProstaglandin-endoperoxide SynthasesEicosanoid-producing enzymes

Mechanism of action

Inhibition of eicosanoid synthesis

Biological functions

InflammationImmune responseRegulation of inflammationMaintenance of homeostasisEicosanoid biosynthesis

Disease associations

InflammationCancerCardiovascular diseaseAsthmaArthritis

Safety considerations

Gastrointestinal side effects (NSAIDs)Cardiovascular risks (COX-2 selective inhibitors)

Interacting drugs

Aspirin

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