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Lipoxygenase Pathway (None)
- Target
- None
- Molecular classification
- Enzyme
01
Overview
The lipoxygenase pathway refers to a series of biochemical reactions catalyzed by the family of lipoxygenase (LOX) enzymes. These are non-heme iron-containing dioxygenases that insert molecular oxygen into polyunsaturated fatty acids (PUFAs), such as arachidonic acid and linoleic acid, resulting in the formation of hydroperoxy derivatives. The pathway is central to the biosynthesis of various lipid mediators, including leukotrienes, hydroxyeicosatetraenoic acids (HETEs), and specialized pro-resolving mediators.
02
Mechanism of action
Inhibition of lipoxygenase enzymes, e.g., 5-LOX, to reduce production of leukotrienes and other inflammatory lipid mediators.
03
Biological functions
Inflammation regulationImmune signalingVascular homeostasis
04
Disease associations
AsthmaAllergyInflammationCardiovascular diseases
05
Interacting drugs
Antileukotriene drugs
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