Little elongation complex subunit 2 (ICE2)

Little elongation complex subunit 2 (ICE2) is a protein-coding gene encoding a component of the little elongation complex (LEC)[1][3][5]. The LEC is essential for the transcription of small nuclear RNA (snRNA) genes by RNA polymerase II, facilitating both polymerase occupancy at these genes and subsequent transcriptional elongation[1][3][5]. ICE2 and other LEC components localize to nuclear subdomains called Cajal bodies, which are involved in the assembly of ribonucleoprotein complexes[3][5]. There are pseudogenes associated with ICE2 on chromosomes 3 and 4[3]. Human ICE2 is referred to by several aliases, including BRCC1, NARG2, and NMDA receptor-regulated protein 2, though relationships to NMDA receptor signaling are unclear in major human curation resources[3][5]. ICE2 is not typically considered a direct therapeutic target such as a receptor, enzyme, transporter, or ion channel; it is a regulatory protein involved in gene expression. Note: - Named aliases such as "breast cancer cell 1" and "NMDA receptor-regulated protein 2" suggest possible historic links to cancer and neuronal signaling, but major functional evidence for these roles in human clinical settings is lacking in current canonical sources[3][5]. - No drugs, mechanisms of action, biomarkers, or safety concerns are described in relation to ICE2 in the literature or databases[3][5]. - Some research in yeast and other species describes a protein called Ice2 involved in endoplasmic reticulum (ER) membrane dynamics, lipid metabolism, and tethering[4][2]. This is a distinct use of the ICE2 name in different organisms (e.g., *Saccharomyces cerevisiae*) and not the same as human ICE2 discussed above.

Other names

Interactor of little elongation complex ELL subunit 2BRCC1NARG2NMDA receptor-regulated protein 2breast cancer cell 1NMDA receptor-regulated gene 2UNQ3101/PRO10100FLJ11896