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Target intelligence / Profile preview
Live attenuated Listeria monocytogenes (LALM)
- Target
- LALM
- Molecular classification
- Bacterium, Vaccine Vector, Immunotherapeutic Agent
01
Overview
Live attenuated Listeria monocytogenes (Lm) is a genetically modified, weakened form of the intracellular bacterial pathogen L. monocytogenes. It is used as an immunotherapeutic agent and vaccine vector to stimulate robust innate and adaptive immune responses, particularly for infectious diseases and cancer immunotherapy. Attenuation typically involves deletion of key virulence genes, which reduces pathogenicity while preserving the bacterium’s ability to infect host cells and induce immunity.
- Other names
- Attenuated LmRecombinant L. monocytogenesImmunotherapeutic Listeria
02
Mechanism of action
Stimulates innate and adaptive immune responses through intracellular infection and antigen presentation. Activates MyD88, STING/IRF3, and inflammasome pathways.
03
Biological functions
Immune StimulationAntigen DeliveryInnate Immune ActivationAdaptive Immune InductionCytokine ProductionT cell activation
04
Disease associations
Infectious Disease (vaccine target)Cancer (immunotherapy)
05
Safety considerations
Risk of systemic infection (reduced by attenuation)Potential for inflammationSafety in immunocompromised patients
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