Target intelligence / Profile preview

Liver and Spleen Harmony

01

Overview

"Liver and Spleen Harmony" is a TCM theoretical concept describing the functional balance between the Liver (responsible for smooth flow of Qi and emotions) and the Spleen (responsible for digestion and transformation of nutrients)[1][2][3][4][5][7][11]. A disruption of this harmony (often called Liver/Spleen disharmony) is believed in TCM to lead to digestive symptoms (such as bloating, fatigue, and poor appetite) and emotional disturbances (such as irritability or anxiety)[1][3][5][7][11]. Restoring harmony—using acupuncture, herbal formulas, dietary adjustment, and stress management—is considered crucial in TCM for the treatment of these patterns[3][5]. This is a TCM system-level diagnosis and NOT a molecular, genetic, or biochemical drug target in the sense of modern pharmacology. It cannot be mapped to a unique standardized protein, gene, or receptor.

Other names
Liver-Spleen harmonyHarmony between Liver and SpleenLiver/Spleen balanceLiver/Spleen disharmony
02

Mechanism of action

In TCM: Harmonizing the flow of Qi, relieving Liver Qi stagnation, strengthening Spleen Qi Promoting digestive function, calming emotional stress

03

Biological functions

In TCM: Regulates digestion and metabolismEmotional regulationGoverns distribution of Qi ("vital energy") and BloodMaintains balance of water, dampness, and metabolism
04

Disease associations

Digestive disorders (as interpreted by TCM, e.g., bloating, poor appetite)Stress and emotional imbalanceMetabolic dysfunction (e.g., stubborn weight gain in TCM view)Non-alcoholic fatty liver disease (NAFLD) from a holistic perspective
05

Safety considerations

Misinterpretation could delay diagnosis/treatment of biomedical diseaseHerb-drug interactions possible with TCM remediesLack of standardization or objective measurement
06

Interacting drugs

TCM herbal formulas (e.g., Xiao Yao San, Tong Xie Yao Fang)

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