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Target intelligence / Profile preview
Plasmodium falciparum Liver-Stage Antigen 1 (LSA-1)
- Target
- LSA-1
- Molecular classification
- Antigen, Protein
01
Overview
Plasmodium falciparum Liver-Stage Antigen 1 (LSA-1) is a protein uniquely expressed by the malaria parasite *P. falciparum* during its development in human liver cells, specifically within infected hepatocytes. LSA-1 plays an essential role during late liver-stage schizogony and is a vaccine candidate due to its restricted expression profile, immunogenicity, and essential function at a bottleneck stage between asymptomatic infection and clinical disease onset.
- Other names
- Liver-stage antigen 1LSA‐¹
02
Mechanism of action
Vaccine development target; induces humoral and cellular immunity
03
Biological functions
Late liver-stage schizogonyExoerythrocytic merozoite releaseImmune response
04
Disease associations
MalariaInfection
05
Safety considerations
Potential for immune evasion by parasiteNeed for effective and durable immune response
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