Target intelligence / Profile preview

LIX1L antisense RNA 1 (LIX1L-AS1)

Target
LIX1L-AS1
Molecular classification
Long non-coding RNA (lncRNA), Antisense RNA
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Overview

LIX1L antisense RNA 1 (LIX1L-AS1) is a long non-coding RNA gene located on human chromosome 1 (1q21.1). It is classified as an antisense RNA, meaning it is transcribed from the opposite strand of the protein-coding LIX1L gene. Antisense lncRNAs, such as LIX1L-AS1, are known to regulate gene expression at multiple levels, including transcriptional and post-transcriptional mechanisms, often by interacting with the sense transcript of the same locus or modulating chromatin states. While many antisense lncRNAs are being investigated for roles in cancer, development, and other biological processes, no specific direct functional studies or validated therapeutic relevance for LIX1L-AS1 have been reported. Disease association databases link the gene locus to Thrombocytopenia-Absent Radius Syndrome and glioma susceptibility, but causative or mechanistic roles of LIX1L-AS1 itself are unclear.

Other names
LIX1L-AS1105371260ENSG00000234222
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Mechanism of action

Not applicable. No drugs target this molecule directly.

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Biological functions

Regulation of gene expression (through antisense RNA mechanisms)Epigenetic regulation (general feature of many lncRNAs, including antisense lncRNAs)
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Disease associations

Cancer (general association for antisense RNAs/lncRNAs; specific roles for LIX1L-AS1 not fully established)Thrombocytopenia-Absent Radius Syndrome (disease associated at the locus)Glioma susceptibility (reported disease association at the locus)

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