LLGL scribble cell polarity complex component 1 (LLGL1)

LLGL scribble cell polarity complex component 1 (LLGL1, commonly known as Lethal giant larvae homolog 1 or Lgl1) is a highly conserved protein that functions as part of the Scribble polarity complex, together with Scribble (Scrib) and Discs large (Dlg)[1][2][3][5]. This complex is essential for the establishment and maintenance of cell polarity, cell adhesion, and directed cell migration in a broad range of tissues and organisms, from fruit flies to mammals[1][3][5]. LLGL1 acts as a scaffold or adaptor protein, interacting with other polarity proteins such as Scrib and Dlg to regulate the assembly and stability of multi-protein complexes crucial for apicobasal polarity and tissue architecture[1][3]. Loss or decreased expression of LLGL1 has been associated with loss of cell polarity, increased cell migration, tissue disorganization, and neoplastic transformation (acting as a tumor suppressor)[1][3][5]. In carcinomas, the Scrib-Lgl-Dlg module is frequently disrupted, contributing to the development and progression of cancer[1][3][5]. LLGL1 also plays a role in the regulation of cell junctions, including both adherens and tight junctions, which impact tissue barrier functions[2][3]. **LLGL1 is not a classical therapeutic target** such as a receptor, enzyme, or transporter. No drugs are currently known to directly interact with it. However, its crucial role in cancer biology and tissue homeostasis makes it an important subject of research for biomarker discovery and understanding the molecular mechanisms underlying tumorigenesis[1][3][5].

Other names

Lethal giant larvae homolog 1Lgl1Lethal giant larvae protein homolog 1Hugl-1