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Target intelligence / Profile preview
LLP homolog, long-term synaptic facilitation factor (LLPH)
- Target
- LLPH
- Molecular classification
- Protein coding gene, RNA binding protein, Nucleolar protein
01
Overview
LLP homolog, long-term synaptic facilitation factor (LLPH) is a protein coding gene primarily expressed in human neurons and nucleoli. LLPH encodes a protein with RNA binding ability and is predicted to be involved in neuronal development, including dendrite extension and regulation of dendritic spine growth, critical for synaptic function and plasticity. The gene is located on chromosome 12 in humans. LLPH is named after the Aplysia protein linked to long-term synaptic facilitation, but its exact biological role in humans appears related to neuronal structure rather than direct signaling. There are currently no drugs targeting human LLPH, and it is not widely recognized as a therapeutic target or biomarker in human disease
- Other names
- LLP homolog, long-term synaptic facilitation factorhuman LAPS18-like proteinhLLPC12orf311190005P17RikLOC100360837RGD1308261Protein LAPS18-likecPERP-GMGC14817LLP homolog, long-term synaptic facilitation (Aplysia)
02
Mechanism of action
None known; no drugs described that directly modulate LLPH
03
Biological functions
RNA bindingDendrite extensionPositive regulation of dendritic spine developmentSynaptic transmission and growth in hippocampal neurons
04
Disease associations
None firmly established; not currently implicated as a major disease driver or therapeutic target
05
Safety considerations
None described; not a therapeutic target with known safety issues
06
Interacting drugs
None identified; not a known target for approved or investigational drugs
07
Biomarkers
None recognized for patient selection or efficacy monitoring
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