lncRNA p53 regulated and ESC associated 1 (LNCPRESS1)

LncRNA p53 regulated and ESC associated 1 (LNCPRESS1) is a human long non-coding RNA transcript that is regulated by p53 and is highly expressed in pluripotent embryonic stem cells where it helps to maintain stem cell identity[1][2][4][7]. It acts primarily by interacting with the chromatin modifier SIRT6, preventing SIRT6 from deacetylating histone H3 at K56 and K9, thereby maintaining transcriptionally active chromatin at pluripotency gene promoters[2][4]. LNCPRESS1 depletion in human embryonic stem cells disrupts pluripotency and induces premature differentiation through loss of key markers (OCT4, NANOG) and activation of differentiation-associated genes[2][4]. Its expression is high in early embryonic development, specifically from oocyte to morula stages, and robustly induced during cellular reprogramming to induced pluripotent stem cells[2]. LNCPRESS1 has been implicated in cancer pathways, and its expression is repressed by p53; in cancer contexts with dysfunctional p53, abnormally high LNCPRESS1 expression may contribute to stem cell–like properties in tumors[6][2]. There are currently no known drugs or direct targeting therapeutics for LNCPRESS1, and it is not formally considered a therapeutic target such as a receptor, enzyme, transporter, or transcription factor. Summary: LNCPRESS1 is a p53-regulated, embryonic stem cell–specific lncRNA that safeguards stem cell pluripotency by modulating chromatin state, mainly by inhibiting SIRT6-mediated deacetylation of pluripotency genes. It is important in developmental regulation, may play roles in cancer, but is not an established therapeutic drug target[2][4][1].

Other names

lncRNA p53 regulated and ESC specific 1lncRNA p53 regulated and ESC specific 1 (alternate spelling variant)LNCPRESS1