LncRNA regulator of macrophage immunity 1 (LROMI1)

LncRNA regulator of macrophage immunity 1 (LROMI1; AC022816.1) is a long noncoding RNA identified as an important regulator of human macrophage immune functions. It is part of an NFκB-dependent lncRNA network that modulates macrophage responses by interacting with mRNA-processing proteins such as hnRNPs. The function of LROMI1 is defined by its ability to fine-tune immune activation in response to pathogens, coordinating transcriptional and post-transcriptional regulatory events essential for the innate immune response. LROMI1 does not encode a protein but acts as a scaffold or guide for molecular interactions that ultimately impact the phenotype and function of immune cells, particularly macrophages[2].

Other names

AC022816.1

Not applicable; there are currently no drugs targeting LROMI1. Mechanistically, LROMI1 functions by binding mRNA processing factors and influencing transcriptional pathways (e.g., NFκB-dependent regulation)[2].