LOC157273 (PPP1R3B-DT)

**PPP1R3B-DT (also called LOC157273 and other aliases)** is a long non-coding RNA located on chromosome 8 intergenic to the protein-coding PPP1R3B gene. It does *not encode a protein* and is mainly studied as a regulatory RNA affecting PPP1R3B expression and hepatic glycogen metabolism. The transcript has gained attention in genetic studies of diabetes and liver function due to its proximity and regulatory relationship to PPP1R3B, but does not act as a receptor, enzyme, or classical drug target. Molecular biology annotations confirm its identity as a lncRNA that may modulate the expression of PPP1R3B and related loci via non-coding mechanisms[4][5].\n\n**Key clarification:**\nThis entry is commonly confused with the protein-coding PPP1R3B gene ("Protein Phosphatase 1 Regulatory Subunit 3B"), which is a drug target involved in glycogen metabolism, diabetes, and cancer[1][2][5]. **PPP1R3B-DT/LOC157273 is NOT a receptor, enzyme, or transporter, but a non-coding intergenic transcript.**

Other names

AC02278.4RP11-10A14.5AP000695.2LOC157273LOC101929128PPP1R3B-DT