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Local tissue metabolism refers to the network of chemical reactions—both anabolic (synthesis) and catabolic (breakdown)—that occur within the cells of a specific tissue to support cellular energy production, biosynthesis of macromolecules, and maintenance of homeostasis[2][3][5][6]. This concept broadly includes pathways such as glycolysis, the tricarboxylic acid (TCA) cycle, fatty acid oxidation, and others, and its dysregulation has been implicated in various diseases, but it is not a distinct molecular target[2][5].
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