LON peptidase N-terminal domain and RING finger protein 2 (LONRF2)

LON peptidase N-terminal domain and RING finger protein 2 (LONRF2) is a protein-coding gene in humans and other vertebrates encoding an enzyme that contains both a peptidase domain related to protein quality control and a RING finger domain implicated in ubiquitin ligase activity[2][4][8]. It is predicted to participate in the ubiquitination and degradation of misfolded or damaged proteins, contributing to cellular protein quality control pathways[2][5][8]. LONRF2 is localized to the cytoplasm and has been associated with ATP-dependent peptidase and ubiquitin protein ligase activities[2][5]. Disorders linked to LONRF2 include Immunodeficiency 15B and childhood germ cell cancer, though specific disease mechanisms have not yet been fully elucidated[2]. No approved drugs or strong biomarker roles have been identified for LONRF2, though its enzymatic function underlies potential therapeutic targeting in disease states characterized by protein misfolding or abnormal ubiquitination[2][5][8].

Other names

Lonrf2LONRF-22900060P06Rik (mouse)si:ch1073- (zebrafish)LON peptidase N-terminal domain and RING finger protein 2

Ubiquitin ligase activity (potential mechanism for any targeted therapeutic modulation); Proteostasis regulation