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Target intelligence / Profile preview
LON peptidase N-terminal domain and ring finger protein 3 (LONRF3)
- Target
- LONRF3
- Molecular classification
- Enzyme (ATP-dependent peptidase), RING finger protein (ubiquitin ligase family), Protein coding gene
01
Overview
LON peptidase N-terminal domain and ring finger protein 3 (LONRF3) is a protein-coding human gene located on the X chromosome. The protein contains a RING finger domain, a conserved motif involved in protein-protein and protein-DNA interactions, likely contributing to regulatory processes such as ubiquitination and protein degradation. It also features a peptidase domain associated with ATP-dependent proteolysis. Multiple transcript variants exist, though their full lengths are not yet fully characterized. Genetic associations link LONRF3 to certain craniofacial and oral developmental disorders, but its broader biological and therapeutic roles remain to be elucidated
- Other names
- LONRF3RNF127 (previous HGNC symbol)4932412G04Rik (mouse)5730439E01Rik (mouse)A830039N02Rik (mouse)
02
Mechanism of action
none documented; drugs targeting LONRF3 have not been identified to date. If targeted, mechanisms would likely involve inhibition of enzymatic or regulatory function (e.g., peptidase or ubiquitin ligase activity)
03
Biological functions
Protein-protein interaction (via RING finger domain)Protein-DNA interactionMay play roles in regulatory processes including protein degradation (inferred from domain structure)Possible involvement in ubiquitination (common with RING finger proteins, but not directly stated in these sources)
04
Disease associations
Cleft palate with or without ankyloglossia (genetic association)Ankyloglossia with or without tooth anomalies (genetic association)Potential modifier in other developmental disorders (only by association)No direct or strong link to cancer, neurodegeneration, or other major diseases currently supported
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