Long-chain fatty acid transport protein 2 (FATP2)

Long-chain fatty acid transport protein 2 (FATP2), encoded by the SLC27A2 gene, is a bifunctional membrane protein with both transporter and enzymatic (acyl-CoA synthetase) activity, primarily expressed in the liver, kidney, and placenta[2][3][7]. FATP2 facilitates the uptake and simultaneous activation (to acyl-CoA esters) of long-chain and very long-chain fatty acids, which is essential for lipid biosynthesis and fatty acid degradation through β-oxidation in peroxisomes and the endoplasmic reticulum. Besides its metabolic roles, FATP2 is implicated in immunosuppression in cancer via the regulation of arachidonic acid uptake and prostaglandin synthesis by myeloid-derived suppressor cells, influences nonalcoholic fatty liver disease progression, and is associated with the pathology of X-linked adrenoleukodystrophy due to compromised peroxisomal fatty acid activation[1][3][5]. Tool compounds inhibiting FATP2 are under investigation for cancer therapy and metabolic disease, but modulation may carry risks of fundamental disruptions in systemic fatty acid metabolism.

Other names

SLC27A2Acyl-CoA synthetase very long-chain 1 (ACSVL1)Fatty acid transport protein 2 (FATP2)Very long-chain acyl-CoA synthetase (VLACS)Fatty-acid-coenzyme A ligase, very long-chain 1Long-chain-fatty-acid--CoA ligasePhytanate--CoA ligaseTHCA-CoA ligaseArachidonate--CoA ligaseSolute carrier family 27 member 2

Inhibition of fatty acid uptake (by blocking transporter function); Inhibition of acyl-CoA synthetase activity (by blocking fatty acid activation)