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Long intergenic non-coding RNA (lincRNA)
- Target
- lincRNA
- Molecular classification
- Non-coding RNA, Long non-coding RNA (lncRNA), Intergenic non-coding RNA
01
Overview
Long intergenic non-coding RNAs (lincRNAs) are RNA transcripts greater than 200 nucleotides in length, transcribed from regions of the genome that do not overlap with protein-coding genes. They belong to the broader category of long non-coding RNAs and are distinguished by their genomic positioning, lack of protein-coding potential, and diverse regulatory functions, including roles in chromatin modification, transcriptional control, and genome architecture. lincRNAs have tissue-specific expression and are implicated in development, disease processes (such as cancer and neurodegeneration), and the fine-tuning of gene expression. Only a small fraction of thousands of lincRNAs have assigned biological functions, and their study is an active and rapidly evolving area of research.
- Other names
- long intergenic non-coding RNAlincRNA
02
Biological functions
Epigenetic regulation (e.g., chromatin remodeling, histone modification)Transcriptional regulation (gene activation/silencing)Scaffold for protein complexesRegulation of genome architecture and nuclear structureRNA stabilization and acting as decoys for other RNA/proteins
03
Disease associations
CancerNeurodegenerative diseaseCardiovascular disease (in development and pathology)Other (autoimmunity, development, etc.)
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