Long intergenic non-coding RNA between ITGB1 and NRP1 (LincIN)

LincIN (long intergenic non-coding RNA between ITGB1 and NRP1), also referred to as ITGB1 divergent transcript or linc-ITGB1, is a long non-coding RNA gene positioned between ITGB1 and NRP1 on the human genome. It does not encode a protein but exerts regulatory functions. LincIN is overexpressed in a variety of human tumors, including breast cancer, hepatocellular carcinoma, and esophageal squamous cell carcinoma. Its increased expression correlates with enhanced cancer cell proliferation, invasion, metastasis, and poor clinical outcome. Mechanistically, it interacts with nuclear factor 90 (NF90) to regulate miR-7 biogenesis and can modulate genes such as p21 at the post-transcriptional level, collectively promoting oncogenic processes. LincIN is being studied as a prognostic marker and an experimental therapeutic target, primarily through RNA silencing approaches.

Other names

LincINITGB1 divergent transcriptlinc-ITGB1long intergenic non-coding RNA between ITGB1 and NRP1

Not applicable in the sense of classical pharmacology. In experimental systems, RNA interference (e.g., shRNA-mediated knockdown) reduces its expression and suppresses tumor cell proliferation and invasion.