Long intergenic non-protein coding RNA 1003 (LINC01003)

**Long intergenic non-protein coding RNA 1003 (LINC01003)** is a long non-coding RNA (lncRNA) gene located on human chromosome 7, which does not encode a protein and acts primarily through RNA-mediated regulatory mechanisms[1][5]. LINC01003 is classified as a long intergenic non-coding RNA, meaning it spans regions between protein-coding genes and exceeds 200 nucleotides in length[1]. It has been implicated in multiple biological processes, including regulation of cell proliferation, cell cycle, migration, and apoptosis, largely via functioning as a competing endogenous RNA (ceRNA) or "sponge" for specific microRNAs, thereby influencing the expression of downstream targets[2][4]. In cancer biology, LINC01003 expression is associated with glioma progression and prognosis, where its upregulation promotes tumorigenic phenotypes through the focal adhesion signaling pathway (including the CAV1-FAK axis)[2]. In multiple myeloma, LINC01003 suppresses malignant features by sponging miR-33a-5p and regulating PIM1 expression, acting as a tumor suppressor[4]. LINC01003 and other lncRNAs are increasingly recognized for their roles as disease biomarkers and and potential (but not established) therapeutic targets[3]. No approved drugs are known to directly target LINC01003, nor have established mechanisms of action or safety concerns been described as of the current literature.

Other names

LINC01003long intergenic non-protein coding RNA 1003