Long intergenic non-protein coding RNA 1050 (LINC01050)

LINC01050 is a long intergenic non-protein coding RNA (lincRNA), part of the wider long non-coding RNA (lncRNA) family, distinguished by lack of protein-coding potential and often displaying regulatory functions on gene expression. LINC01050 is significantly upregulated in gastric cancer tissues compared to non-tumor tissues. Mechanistically, it acts as a competing endogenous RNA (“sponge”) for the microRNA miR-7161-3p, resulting in derepression and increased expression of SPZ1, a factor involved in tumor growth and metastasis. Expression of LINC01050 is activated by the transcription factor c-Myc. High levels of LINC01050 promote gastric cancer cell proliferation, migration, invasion, and epithelial-mesenchymal transition, and are associated with poor patient prognosis. Knockdown of LINC01050 in gastric cancer models inhibits tumor growth and metastasis, establishing LINC01050 as a potential diagnostic, prognostic, and therapeutic target in gastric cancer. Long intergenic non-coding RNAs such as LINC01050 are typically more than 200 nucleotides in length and do not overlap with protein-coding genes. They can regulate neighboring and distant genes through mechanisms including chromatin remodeling, transcriptional regulation, and molecular “sponging” of microRNAs. Summary: LINC01050 is a cancer-associated, non-coding regulatory RNA that functions as a ceRNA in gastric cancer and may serve as a potential biomarker and therapeutic target, despite no drugs currently targeting it directly.

Other names

LINC01050long non-coding RNA LINC01050

Not applicable (no direct drug mechanism; experimental modulation involves RNA interference or expression vectors in research). Endogenous mechanism: acts as a molecular sponge for miR-7161-3p, derepressing SPZ1 expression.